"Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity". Coria-Téllez Efigenia Montalvo-Gónzalez Elhadi M. "Annonaceous Acetogenins: Recent Progress". ^ a b c Alali, Feras Q Liu, Xiao-Xi McLaughlin, Jerry L (1999).Progress in the Chemistry of Organic Natural Products. ^ Liaw, Chih-Chuang Liou, Jing-Ru Wu, Tung-Ying Chang, Fang-Rong Wu, Yang-Chang (2016)."Acetogenins from Annonaceae: Recent Progress in Isolation, Synthesis and Mechanisms of Action". "Recent Progress on the Total Synthesis of Acetogenins from Annonaceae" (PDF). Mechanism of action Īcetogenins inhibit NADH dehydrogenase, a key enzyme in energy metabolism. Purified acetogenins and crude extracts of the common North American pawpaw ( Asimina triloba) or the soursop ( Annona muricata) remain under laboratory studies. Examples of R-groups for selected acetogenins CompoundĪcetogenins have been investigated for their biological properties, but are a concern due to neurotoxicity. These THF rings are located along the hydrocarbon chain, along with a number of oxygenated moieties (hydroxyls, acetoxyls, ketones, epoxides) and/or double bonds. Structurally, acetogenins are a series of C-35/C-37 compounds usually characterized by a long aliphatic chain bearing a terminal methyl-substituted α,β-unsaturated γ-lactone ring, as well as one to three tetrahydrofuran (THF) rings. Acetogenin terminal lactone ring core unit (unsaturated)
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